Functional role of oligomerization for bacterial and plant SWEET sugar transporter family
Copyright policy )Functional role of oligomerization for bacterial and plant SWEET sugar transporter family
Significance SWEET sugar transporter homologs from bacteria were identified and named SemiSWEETs. They are small proteins with only three transmembrane domains (TMs); they are too small to create pores by themselves, but likely, they assemble multiple 3-TMs into a complex. SemiSWEETs are related to SWEETs, which play important roles in intercellular and interorgan sugar translocation in plants, and they are found in animals. SWEETs have fused two 3-TM units through a linker. However, SWEETs seem to be too small to transport sugars on their own. Here, we show that SWEET function requires assembly into oligomers, indicating that a pore requires at least an SWEET dimer.
- Nanjing Agricultural University China (People's Republic of)
- Carnegie Institution for Science United States
- Michigan State University United States
Sucrose, Genetic Complementation Test, Green Fluorescent Proteins, Arabidopsis, Membrane Transport Proteins, Biological Transport, Saccharomyces cerevisiae, Models, Biological, Protein Structure, Secondary, Structure-Activity Relationship, Glucose, Bacterial Proteins, Multigene Family, Carbohydrate Metabolism, Bradyrhizobium, Amino Acids, Protein Multimerization, Phylogeny, Plant Proteins, Signal Transduction
Sucrose, Genetic Complementation Test, Green Fluorescent Proteins, Arabidopsis, Membrane Transport Proteins, Biological Transport, Saccharomyces cerevisiae, Models, Biological, Protein Structure, Secondary, Structure-Activity Relationship, Glucose, Bacterial Proteins, Multigene Family, Carbohydrate Metabolism, Bradyrhizobium, Amino Acids, Protein Multimerization, Phylogeny, Plant Proteins, Signal Transduction
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