Ovarian enzyme activities in women with polycystic ovary syndrome
Copyright policy )Ovarian enzyme activities in women with polycystic ovary syndrome
Studies using primary ovarian tissue and cultured human theca and granulosa cells have shown that steroidogenic enzyme activities are up-regulated in theca cells in polycystic ovary syndrome (PCOS). Although granulosa cells in arrested follicles in PCOS fail to express significant amounts of aromatase, there is an overexpression of 5alpha-reductase activity and premature expression of cholesterol side-chain cleavage cytochrome P450.
- University of California, Los Angeles United States
Adult, Aromatase, Granulosa Cells, 3-Oxo-5-alpha-Steroid 4-Dehydrogenase, Theca Cells, Ovary, Humans, Female, Cholesterol Side-Chain Cleavage Enzyme, Polycystic Ovary Syndrome
Adult, Aromatase, Granulosa Cells, 3-Oxo-5-alpha-Steroid 4-Dehydrogenase, Theca Cells, Ovary, Humans, Female, Cholesterol Side-Chain Cleavage Enzyme, Polycystic Ovary Syndrome
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