FGF20 and Parkinson's disease: No evidence of association or pathogenicity via α‐synuclein expression
Copyright policy )FGF20 and Parkinson's disease: No evidence of association or pathogenicity via α‐synuclein expression
AbstractGenetic variation in fibroblast growth factor 20 (FGF20) has been associated with risk of Parkinson's disease (PD). Functional evidence suggested the T allele of one SNP, rs12720208 C/T, altered PD risk by increasing FGF20 and α‐synuclein protein levels. Herein we report our association study of FGF20 and PD risk in four patient‐control series (total: 1,262 patients and 1,881 controls), and measurements of FGF20 and α‐synuclein protein levels in brain samples (nine patients). We found no evidence of association between FGF20 variability and PD risk, and no relationship between the rs12720208 genotype, FGF20 and α‐synuclein protein levels. © 2009 Movement Disorder Society
- Norwegian University of Science and Technology Norway
- Trinity College Dublin Ireland
- University College Dublin Ireland
- Mayo Clinic United States
- Mater Misericordiae Hospital Australia
Adult, Aged, 80 and over, Fibroblast Growth Factors, Male, alpha-Synuclein, Humans, Female, Parkinson Disease, Middle Aged, Aged
Adult, Aged, 80 and over, Fibroblast Growth Factors, Male, alpha-Synuclein, Humans, Female, Parkinson Disease, Middle Aged, Aged
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