Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways
Copyright policy )Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways
Signaling pathways essential for axon regeneration, but not for neuron development or function, are particularly well suited targets for therapeutic intervention. We find that the parallel PMK-3(p38) and KGB-1(JNK) MAPK pathways must be coordinately activated to promote axon regeneration. Axon regeneration fails if the activity of either pathway is absent. These two MAPKs are coregulated by the E3 ubiquitin ligase RPM-1(Phr1) via targeted degradation of the MAPKKKs DLK-1 and MLK-1 and by the MAPK phosphatase VHP-1(MKP7), which negatively regulates both PMK-3(p38) and KGB-1(JNK).
- Nagoya University Japan
- University of Utah United States
Enzyme Activation, Base Sequence, MAP Kinase Kinase 4, Animals, p38 Mitogen-Activated Protein Kinases, Axons, DNA Primers, Nerve Regeneration, Signal Transduction
Enzyme Activation, Base Sequence, MAP Kinase Kinase 4, Animals, p38 Mitogen-Activated Protein Kinases, Axons, DNA Primers, Nerve Regeneration, Signal Transduction
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