Mutations in Krüppel-like factor 1 cause transfusion-dependent hemolytic anemia and persistence of embryonic globin gene expression
Copyright policy )Mutations in Krüppel-like factor 1 cause transfusion-dependent hemolytic anemia and persistence of embryonic globin gene expression
Key Points KLF1 mutations cause severe congenital hemolytic anemia associated with a deficiency of red cell pyruvate kinase. A severe KLF1 deficiency causes hereditary persistence of embryonic globin synthesis.
- MRC Weatherall Institute of Molecular Medicine United Kingdom
- University of Oxford United Kingdom
- Ministry of Public Health Thailand
- Erasmus University Rotterdam Netherlands
- Medical Research Council United Kingdom
Adult, Erythrocyte Indices, Male, Anemia, Hemolytic, Erythrocytes, Adolescent, Molecular Sequence Data, EMC MGC-02-13-02, Kruppel-Like Transcription Factors, Infant, Gene Expression Regulation, Child, Preschool, Gene Order, Mutation, Humans, Female, Amino Acid Sequence, Child, Conserved Sequence, Fetal Hemoglobin, Protein Binding
Adult, Erythrocyte Indices, Male, Anemia, Hemolytic, Erythrocytes, Adolescent, Molecular Sequence Data, EMC MGC-02-13-02, Kruppel-Like Transcription Factors, Infant, Gene Expression Regulation, Child, Preschool, Gene Order, Mutation, Humans, Female, Amino Acid Sequence, Child, Conserved Sequence, Fetal Hemoglobin, Protein Binding
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).82 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!