Uncharged tRNA and Sensing of Amino Acid Deficiency in Mammalian Piriform Cortex
Copyright policy )Uncharged tRNA and Sensing of Amino Acid Deficiency in Mammalian Piriform Cortex
Recognizing a deficiency of indispensable amino acids (IAAs) for protein synthesis is vital for dietary selection in metazoans, including humans. Cells in the brain's anterior piriform cortex (APC) are sensitive to IAA deficiency, signaling diet rejection and foraging for complementary IAA sources, but the mechanism is unknown. Here we report that the mechanism for recognizing IAA-deficient foods follows the conserved general control (GC) system, wherein uncharged transfer RNA induces phosphorylation of eukaryotic initiation factor 2 (eIF2) via the GC nonderepressing 2 (GCN2) kinase. Thus, a basic mechanism of nutritional stress management functions in mammalian brain to guide food selection for survival.
- Pennsylvania State University United States
- University of Pittsburgh United States
- University of California, Davis United States
- Indiana University United States
- Indiana University School of Medicine United States
Threonine, Acylation, Eukaryotic Initiation Factor-2, Stereoisomerism, Olfactory Pathways, Protein Serine-Threonine Kinases, Diet, Rats, Mice, Inbred C57BL, Eating, Food Preferences, Mice, eIF-2 Kinase, RNA, Transfer, Food, Leucine, Animals, Amino Acids, Essential, Phosphorylation, Protein Kinases
Threonine, Acylation, Eukaryotic Initiation Factor-2, Stereoisomerism, Olfactory Pathways, Protein Serine-Threonine Kinases, Diet, Rats, Mice, Inbred C57BL, Eating, Food Preferences, Mice, eIF-2 Kinase, RNA, Transfer, Food, Leucine, Animals, Amino Acids, Essential, Phosphorylation, Protein Kinases
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).301 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!