The Mouse Homolog of the Wiskott–Aldrich Syndrome Protein (WASP) Gene Is Highly Conserved and Maps near the Scurfy (sf) Mutation on the X Chromosome
Copyright policy )The Mouse Homolog of the Wiskott–Aldrich Syndrome Protein (WASP) Gene Is Highly Conserved and Maps near the Scurfy (sf) Mutation on the X Chromosome
The mouse WASP gene, the homolog of the gene mutated in Wiskott-Aldrich syndrome, has been isolated and sequenced. the predicted amino acid sequence is 86% identical to the human WASP sequence. A distinct feature of the mouse gene is an expanded polymorphic GGA trinucleotide repeat that codes for polyglycine and varies from 15 to 17 triplets in different Mus musculus strains. The genomic structure of the mouse WASP gene is expressed as an approximately 2.4-kb mRNA in thymus and spleen. Chromosomal mapping in an interspecific M. Musculus/M. spretus backcross placed the Wasp locus near the centromere of the mouse X chromosome, inseparable from Gata1, Tcfe3, and scurfy (sf). This localization makes Wasp a candidate for involvement in scurfy, a T cell-mediated fatal lymphoreticular disease of mice that has previously been proposed as a mouse homolog of Wiskott-Aldrich syndrome. Northern analysis of sf tissue samples indicated the presence of WASP mRNA in liver and skin, presumably as a consequence of lymphocytic infiltration, but non abnormalities in the amount or size of mRNA present.
- University of Tennessee at Knoxville United States
- Oak Ridge National Laboratory United States
- Howard Hughes Medical Institute United States
- Stanford Medicine United States
- Stanford University United States
Male, Genomic Library, X Chromosome, Base Sequence, Sequence Homology, Amino Acid, Genetic Linkage, Molecular Sequence Data, Chromosome Mapping, Proteins, Mice, Inbred Strains, Polymerase Chain Reaction, Wiskott-Aldrich Syndrome, Mice, Sequence Homology, Nucleic Acid, Animals, Humans, Female, Amino Acid Sequence, Crosses, Genetic, Wiskott-Aldrich Syndrome Protein
Male, Genomic Library, X Chromosome, Base Sequence, Sequence Homology, Amino Acid, Genetic Linkage, Molecular Sequence Data, Chromosome Mapping, Proteins, Mice, Inbred Strains, Polymerase Chain Reaction, Wiskott-Aldrich Syndrome, Mice, Sequence Homology, Nucleic Acid, Animals, Humans, Female, Amino Acid Sequence, Crosses, Genetic, Wiskott-Aldrich Syndrome Protein
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).41 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!