Immobilization stress elevates IP3 receptor mRNA in adult rat hearts in a glucocorticoid‐dependent manner
Copyright policy )Immobilization stress elevates IP3 receptor mRNA in adult rat hearts in a glucocorticoid‐dependent manner
Gene expression of the type 1 and 2 inositol 1,4,5‐trisphosphate (IP3) receptors in the rat cardiac atria and ventricles and their possible modulation by single immobilization stress was studied. Single immobilization stress significantly elevated mRNA levels for both types of these receptors. To evaluate the involvement of glucocorticoids in the modulation of the gene expression of IP3 receptors by immobilization stress, we used adrenalectomized and/or hypophysectomized rats. Since adrenalectomy and/or hypophysectomy completely abolished increase in IP3 receptor's mRNA levels after the immobilization, we conclude that immobilization stress elevates mRNA of type 1 and 2 IP3 receptors, mainly through the glucocorticoid responsive element.
- Institute of Experimental Endocrinology Slovakia
- Slovak Academy of Sciences Slovakia
- Slovak Academy of Science Slovakia
- Institute of Molecular Genetics Russian Federation
- Russian Academy of Sciences Russian Federation
Male, Base Sequence, Rat heart, Myocardium, Atrial function, Ca-channels, Blotting, Western, Receptors, Cytoplasmic and Nuclear, Rats, Rats, Sprague-Dawley, Immobilization, Gene Expression Regulation, Stress, Physiological, Animals, Inositol 1,4,5-Trisphosphate Receptors, Inositol 1,4,5-trisphosphate receptors, Calcium Channels, RNA, Messenger, Glucocorticoid modulation, DNA Primers
Male, Base Sequence, Rat heart, Myocardium, Atrial function, Ca-channels, Blotting, Western, Receptors, Cytoplasmic and Nuclear, Rats, Rats, Sprague-Dawley, Immobilization, Gene Expression Regulation, Stress, Physiological, Animals, Inositol 1,4,5-Trisphosphate Receptors, Inositol 1,4,5-trisphosphate receptors, Calcium Channels, RNA, Messenger, Glucocorticoid modulation, DNA Primers
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