The chemokine CCL5 regulates the in vivo cell surface expression of its receptor, CCR5
Copyright policy ) Yea-Lih, Lin; Clément, Mettling; Pierre, Portalès; Régine, Rouzier; Jacques, Clot; Jacques, Reynes; Pierre, Corbeau;
The chemokine CCL5 regulates the in vivo cell surface expression of its receptor, CCR5
The efficiency of CCR5 as an HIV coreceptor is strongly dependent on its level of cell surface expression. Therefore, it is of major importance to identify the factors that regulate cell surface density of CCR5. Among the chemokines that bind to CCR5, and induce its internalization, CCL5 is the most abundant in vivo. We show that the level of CCL5 production is a main factor determining CD4+ T cell surface CCR5 density.
CD4-Positive T-Lymphocytes, Gene Expression Regulation, Receptors, CCR5, Leukocytes, Mononuclear, Humans, RNA, Messenger, Chemokine CCL5
CD4-Positive T-Lymphocytes, Gene Expression Regulation, Receptors, CCR5, Leukocytes, Mononuclear, Humans, RNA, Messenger, Chemokine CCL5
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).24 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
citations
Citations provided by BIP!
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 24
Average
Top 10%
Top 10%
