TRPM2-mediated intracellular Zn2+ release triggers pancreatic β-cell death
Copyright policy ) Paul T, Manna; Tim S, Munsey; Nada, Abuarab; Fangfang, Li; Aruna, Asipu; Gareth, Howell; Alicia, Sedo; +5 Authors
Paul T, Manna; Tim S, Munsey; Nada, Abuarab; Fangfang, Li; Aruna, Asipu; Gareth, Howell; Alicia, Sedo; Wei, Yang; Jacqui, Naylor; David J, Beech; Lin-Hua, Jiang; Asipu, Sivaprasadarao;
TRPM2-mediated intracellular Zn2+ release triggers pancreatic β-cell death
Activation of transient receptor potential (melastatin) 2 (TRPM2) channels during oxidative stress promotes pancreatic β-cell death, resulting in hyperglycaemia. Cell death is caused by TRPM2-mediated Ca2+-induced intracellular Zn2+ release, but not by Ca2+ alone.
- King Saud bin Abdulaziz University for Health Sciences Saudi Arabia
- Wellcome Trust United Kingdom
- University of Leeds United Kingdom
Intracellular Fluid, Mice, Knockout, Cell Death, TRPM Cation Channels, Mice, Inbred C57BL, Mice, Zinc, HEK293 Cells, Insulin-Secreting Cells, Animals, Humans, Reactive Oxygen Species
Intracellular Fluid, Mice, Knockout, Cell Death, TRPM Cation Channels, Mice, Inbred C57BL, Mice, Zinc, HEK293 Cells, Insulin-Secreting Cells, Animals, Humans, Reactive Oxygen Species
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).42 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
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Citations provided by BIP!
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 42
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