Name: Antigen receptor‐mediated calcium signals in B cells as revealed by confocal fluorescence microscopy
Keywords: Cell Nucleus, B cell, Cytoplasm, Lymphoma, B-Cell, Receptors, Antigen, B-Cell, Immunoglobulin D, Calcium signal, Nucleus, Antibodies, Kinetics

descriptionPublicationkeyboard_double_arrow_right Article 24 Jun 1991 English Publisher:WileyJournal:FEBS Letters, volume 284, pages 249-251 (issn: 0014-5793, eissn: 1873-3468,

Authors: Yamada, Hiroshi; Mizuguchi, Junichiro; Nakanishi, Mamoru;

doi: 10.1016/0014-5793(91)80696-z

pmid: 2060644

Antigen receptor‐mediated calcium signals in B cells as revealed by confocal fluorescence microscopy

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Abstract

A confocal fluorescence microscope was used to study the antigen receptor‐mediated calcium signals in B cells. Anti‐IgD binding to B lymphoma cells (BAL17) increased the intracellular calcium concentration with short lag times. Confocal fluorescence images of the fluo‐3‐loaded BAL17 cells showed that the intracellular calcium ion concentrations increased non‐homogeneously, suggesting that the calcium signals transferred not only to the cytoplasm but also to the nucleus.

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Nagoya City University
Japan

Keywords

Cell Nucleus, B cell, Cytoplasm, Lymphoma, B-Cell, Receptors, Antigen, B-Cell, Immunoglobulin D, Calcium signal, Nucleus, Antibodies, Kinetics, Microscopy, Fluorescence, Antigen receptor, Image Processing, Computer-Assisted, Tumor Cells, Cultured, Calcium, Confocal fluorescence microscope, Signal Transduction

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