Multiple Pathways Promote Short-Sequence Recombination in Saccharomyces cerevisiae
Copyright policy )Multiple Pathways Promote Short-Sequence Recombination in Saccharomyces cerevisiae
In the budding yeast Saccharomyces cerevisiae, null alleles of several DNA repair and recombination genes confer defects in recombination that grow more severe with decreasing sequence length, indicating that they are required for short-sequence recombination (SSR). RAD1 and RAD10, which encode the subunits of the structure-specific endonuclease Rad1/10, are critical for SSR. MRE11, RAD50, and XRS2, which encode the subunits of M/R/X, another complex with nuclease activity, are also crucially important. Genetic evidence suggests that Rad1/10 and M/R/X act on the same class of substrates during SSR. MSH2 and MSH3, which encode subunits of Msh2/3, a complex active during mismatch repair and recombination, are also important for SSR but play a more restricted role. Additional evidence suggests that SSR is distinct from nonhomologous end joining and is superimposed upon basal homologous recombination.
- Beckman Research Institute United States
- City Of Hope National Medical Center United States
Recombination, Genetic, Endodeoxyribonucleases, Saccharomyces cerevisiae Proteins, DNA Repair, Macromolecular Substances, Single-Strand Specific DNA and RNA Endonucleases, Oligonucleotides, Saccharomyces cerevisiae, Endonucleases, DNA-Binding Proteins, Fungal Proteins, DNA Repair Enzymes, Exodeoxyribonucleases, MutS Homolog 2 Protein, MutS Homolog 3 Protein, Mutation, DNA, Fungal
Recombination, Genetic, Endodeoxyribonucleases, Saccharomyces cerevisiae Proteins, DNA Repair, Macromolecular Substances, Single-Strand Specific DNA and RNA Endonucleases, Oligonucleotides, Saccharomyces cerevisiae, Endonucleases, DNA-Binding Proteins, Fungal Proteins, DNA Repair Enzymes, Exodeoxyribonucleases, MutS Homolog 2 Protein, MutS Homolog 3 Protein, Mutation, DNA, Fungal
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).13 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!