Interaction between c-Abl and Arg Tyrosine Kinases and Proteasome Subunit PSMA7 Regulates Proteasome Degradation
Copyright policy )Interaction between c-Abl and Arg Tyrosine Kinases and Proteasome Subunit PSMA7 Regulates Proteasome Degradation
Proteasome-mediated proteolysis is a primary protein degradation pathway in cells. The present study demonstrates that c-Abl and Arg (abl-related gene) tyrosine kinases associate with and phosphorylate the proteasome PSMA7 (alpha4) subunit at Tyr-153. Consequently, proteasome-dependent proteolysis is compromised. Notably, cells expressing a phosphorylation mutant of PSMA7(Y153F) display impaired G1/S transition and S/G2 progression, highlighting the biological significance of tyrosine phosphorylation of a proteasome subunit as an important cellular regulatory control.
- PEKING UNION MEDICAL COLLEGE China (People's Republic of)
- Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. China (People's Republic of)
- Chinese Academy of Medical Sciences & Peking Union Medical College China (People's Republic of)
Proteasome Endopeptidase Complex, Cell Cycle, Cell Biology, Protein-Tyrosine Kinases, Models, Biological, Cysteine Endopeptidases, Mice, Oxidative Stress, Gene Expression Regulation, Radiation, Ionizing, Animals, Humans, Phosphorylation, K562 Cells, Proto-Oncogene Proteins c-abl, Molecular Biology, Protein Processing, Post-Translational, Cells, Cultured, Protein Binding
Proteasome Endopeptidase Complex, Cell Cycle, Cell Biology, Protein-Tyrosine Kinases, Models, Biological, Cysteine Endopeptidases, Mice, Oxidative Stress, Gene Expression Regulation, Radiation, Ionizing, Animals, Humans, Phosphorylation, K562 Cells, Proto-Oncogene Proteins c-abl, Molecular Biology, Protein Processing, Post-Translational, Cells, Cultured, Protein Binding
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