Effects of CCR5-Δ 32, CCR2-64I, and SDF-1 3′A Alleles on HIV-1 Disease Progression: An International Meta-Analysis of Individual-Patient Data
Copyright policy )Effects of CCR5-Δ 32, CCR2-64I, and SDF-1 3′A Alleles on HIV-1 Disease Progression: An International Meta-Analysis of Individual-Patient Data
Studies relating certain chemokine and chemokine receptor gene alleles with the outcome of HIV-1 infection have yielded inconsistent results.To examine postulated associations of genetic alleles with HIV-1 disease progression.Meta-analysis of individual-patient data.19 prospective cohort studies and case-control studies from the United States, Europe, and Australia.Patients with HIV-1 infection who were of European or African descent.Time to AIDS, death, and death after AIDS and HIV-1 RNA level at study entry or soon after seroconversion. Data were combined with fixed-effects and random-effects models.Both the CCR5-Delta32 and CCR2-64I alleles were associated with a decreased risk for progression to AIDS (relative hazard among seroconverters, 0.74 and 0.76, respectively; P = 0.01 for both), a decreased risk for death (relative hazard among seroconverters, 0.64 and 0.74; P 0.5 for all).The CCR5-Delta32 and CCR2-64I alleles had a strong protective effect on progression of HIV-1 infection, but SDF-1 3'A homozygosity carried no such protection.
- University of Copenhagen Denmark
- Sorbonne Paris Cité France
- National Institutes of Health United States
- Amsterdam UMC Netherlands
- University of Copenhagen Denmark
Heterozygote, Receptors, CCR5, Receptors, CCR2, HIV Infections, RNA/metabolism, Receptors, Journal Article, Humans, Receptors, CCR5/*genetics, Alleles, Proportional Hazards Models, CXC, Acquired Immunodeficiency Syndrome, *HIV-1/genetics, Chemokines, CXC/*genetics, Chemokine CXCL12, Receptors, Chemokine/*genetics, Chemokine, Acquired Immunodeficiency Syndrome/genetics/mortality, Disease Progression, HIV-1, CCR2, RNA, Regression Analysis, Receptors, Chemokine, Chemokines, HIV Infections/*genetics, CCR5, Chemokines, CXC, Meta-Analysis
Heterozygote, Receptors, CCR5, Receptors, CCR2, HIV Infections, RNA/metabolism, Receptors, Journal Article, Humans, Receptors, CCR5/*genetics, Alleles, Proportional Hazards Models, CXC, Acquired Immunodeficiency Syndrome, *HIV-1/genetics, Chemokines, CXC/*genetics, Chemokine CXCL12, Receptors, Chemokine/*genetics, Chemokine, Acquired Immunodeficiency Syndrome/genetics/mortality, Disease Progression, HIV-1, CCR2, RNA, Regression Analysis, Receptors, Chemokine, Chemokines, HIV Infections/*genetics, CCR5, Chemokines, CXC, Meta-Analysis
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