Lack of Association Between Genetic Polymorphisms of ARRB2 and Alcohol Dependence in a Caucasian Population
Copyright policy )Lack of Association Between Genetic Polymorphisms of ARRB2 and Alcohol Dependence in a Caucasian Population
Beta-arrestin 2 ( ARRB2 ) is expressed in the brain and it is involved in μ-opiate and dopamine D2 receptor signaling (Lefkowitz and Shenoy, 2005). It has recently been shown that the ARRB2 genotype may contribute to the inter-individual variability in the response to methadone maintenance treatment (Oneda et al ., 2010). In addition, ARRB2 modulates the acute response to ethanol and mediates its rewarding effects in mice (Bjork et al ., 2008). To investigate the significance of this finding in human, genomic DNA was collected from 45 males and 28 females of Caucasian origin, 18 years old or older, who met the criteria for the diagnosis of alcohol dependence (Diagnostic and Statistical Manual of Mental Disorders, DSM-IV, American Psychiatric Association, 1994). Potential study subjects were excluded if they had …
- Biochimie et Psychopharmacologie clinique Centre de Neurosciences Psychiatriques Département de Psychiatrie - CHUV Switzerland
- University of Geneva Switzerland
- Hôpital de Cery Switzerland
- School of Pharmaceutical Sciences Switzerland
- University Hospital of Geneva Switzerland
Male, 10039 Institute of Medical Genetics, Arrestins, 3005 Toxicology, 610 Medicine & health, 2701 Medicine (miscellaneous), Polymorphism, Single Nucleotide, beta-Arrestin 2, White People, 2738 Psychiatry and Mental Health, Alcoholism, 570 Life sciences; biology, Humans, Female, Genetic Association Studies, beta-Arrestins
Male, 10039 Institute of Medical Genetics, Arrestins, 3005 Toxicology, 610 Medicine & health, 2701 Medicine (miscellaneous), Polymorphism, Single Nucleotide, beta-Arrestin 2, White People, 2738 Psychiatry and Mental Health, Alcoholism, 570 Life sciences; biology, Humans, Female, Genetic Association Studies, beta-Arrestins
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