Cloning and Expression of Primate Daxx cDNAs and Mapping of the Human Gene to Chromosome 6p21.3 in the MHC Region
Copyright policy )Cloning and Expression of Primate Daxx cDNAs and Mapping of the Human Gene to Chromosome 6p21.3 in the MHC Region
Murine Daxx, a protein that binds to Fas and enhances Fas-mediated apoptosis through a signal transduction pathway involving the Jun amino-terminal kinase, was recently described. Here we report the cloning of human and monkey Daxx cDNAs, the widespread expression of Daxx mRNA in human tissues, and the mapping of the human Daxx gene to 6p21.3 in the major histocompatibility complex (MHC) region. The location of the Daxx gene, which is implicated in the pathway for deletion of autoreactive lymphocytes, in the MHC region may shed light on the genetic basis of autoimmune diseases.
- University Medical Center United States
- University of Pennsylvania United States
Adult, DNA, Complementary, Base Sequence, Intracellular Signaling Peptides and Proteins, Chromosome Mapping, Gene Expression, Apoptosis, DNA, Haplorhini, Major Histocompatibility Complex, COS Cells, Animals, Humans, Chromosomes, Human, Pair 6, Amino Acid Sequence, Cloning, Molecular, Carrier Proteins, Co-Repressor Proteins, Adaptor Proteins, Signal Transducing, HeLa Cells
Adult, DNA, Complementary, Base Sequence, Intracellular Signaling Peptides and Proteins, Chromosome Mapping, Gene Expression, Apoptosis, DNA, Haplorhini, Major Histocompatibility Complex, COS Cells, Animals, Humans, Chromosomes, Human, Pair 6, Amino Acid Sequence, Cloning, Molecular, Carrier Proteins, Co-Repressor Proteins, Adaptor Proteins, Signal Transducing, HeLa Cells
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