Nipah Virus Edits Its P Gene at High Frequency To Express the V and W Proteins
Copyright policy )Nipah Virus Edits Its P Gene at High Frequency To Express the V and W Proteins
ABSTRACT Nipah virus (NiV) is predicted to encode four proteins from its P gene (P, V, W, and C) via mRNA editing and an alternate open reading frame. By use of specific antibodies, the expression of the V, W, and C proteins in NiV-infected cells has now been confirmed. Analysis of the P-gene transcripts shows a ratio of P:V:W mRNA of 1:1:1, but this differs over time, with greater proportions of V and W transcripts observed as the infection progresses. Eighty-two percent of transcripts are edited, with up to 11 G insertions observed. This exceptionally high editing frequency ensures expression of the V and W proteins.
- Icahn School of Medicine at Mount Sinai United States
- French Institute of Health and Medical Research France
- University of Lyon System France
Gene Expression Regulation, Viral, Viral Structural Proteins, Nipah Virus, Phosphoproteins, Cell Line, Mutagenesis, Insertional, Viral Proteins, Humans, RNA, Viral, RNA, Messenger
Gene Expression Regulation, Viral, Viral Structural Proteins, Nipah Virus, Phosphoproteins, Cell Line, Mutagenesis, Insertional, Viral Proteins, Humans, RNA, Viral, RNA, Messenger
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