Rescue of Cyclin D1 Deficiency by Knockin Cyclin E
Copyright policy )Rescue of Cyclin D1 Deficiency by Knockin Cyclin E
D-type cyclins and cyclin E represent two very distinct classes of mammalian G1 cyclins. We have generated a mouse strain in which the coding sequences of the cyclin D1 gene (Ccnd1) have been deleted and replaced by those of human cyclin E (CCNE). In the tissues and cells of these mice, the expression pattern of human cyclin E faithfully reproduces that normally associated with mouse cyclin D1. The replacement of cyclin D1 with cyclin E rescues all phenotypic manifestations of cyclin D1 deficiency and restores normal development in cyclin D1-dependent tissues. Thus, cyclin E can functionally replace cyclin D1. Our analyses suggest that cyclin E is the major downstream target of cyclin D1.
- Utrecht University Netherlands
- Dana-Farber Cancer Institute United States
- Harvard University United States
- Massachusetts Institute of Technology United States
- Tufts University United States
Cyclin-E: ge, 610, df, Retina, Algemeen onderzoek, Geneeskunde, Mice, SUPPORT-U-S-GOVT-P-H-S, 616, Cyclin E, Animals, Humans, Cyclin D1, Geneeskunde(GENK), Retina: me, SUPPORT-NON-U-S-GOVT, Internal medicine, Cyclin-D1: ge, Econometric and Statistical Methods: General, me, Biochemistry, Genetics and Molecular Biology(all), Mice-Inbred-C57BL, Receptors-Estrogen: me, Mice, Inbred C57BL, Phenotype, Receptors, Estrogen, Human
Cyclin-E: ge, 610, df, Retina, Algemeen onderzoek, Geneeskunde, Mice, SUPPORT-U-S-GOVT-P-H-S, 616, Cyclin E, Animals, Humans, Cyclin D1, Geneeskunde(GENK), Retina: me, SUPPORT-NON-U-S-GOVT, Internal medicine, Cyclin-D1: ge, Econometric and Statistical Methods: General, me, Biochemistry, Genetics and Molecular Biology(all), Mice-Inbred-C57BL, Receptors-Estrogen: me, Mice, Inbred C57BL, Phenotype, Receptors, Estrogen, Human
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