INDUCTION OF INDUCIBLE NITRIC OXIDE SYNTHASE BY LIPOPOLYSACCHARIDE/INTERFERON GAMMA AND SEPSIS DOWN-REGULATES 5-LIPOXYGENASE METABOLISM IN MURINE ALVEOLAR MACROPHAGES
Copyright policy )INDUCTION OF INDUCIBLE NITRIC OXIDE SYNTHASE BY LIPOPOLYSACCHARIDE/INTERFERON GAMMA AND SEPSIS DOWN-REGULATES 5-LIPOXYGENASE METABOLISM IN MURINE ALVEOLAR MACROPHAGES
Pretreatment with lipopolysaccharide (LPS) suppresses rat alveolar macrophage leukotriene synthesis in a nitric oxide (NO)-dependent mechanism. The authors examined the effect of NO on alveolar macrophage leukotriene synthesis following in vitro and in vivo models of sepsis. Treatment of alveolar macrophages from inducible NO synthase (iNOS) wild-type but not knock-out mice with LPS inhibited leukotriene synthesis. iNOS was induced early in alveolar macrophages from cecal ligation and puncture rats and mice compared to sham animals with associated reduced leukotriene synthesis. iNOS knock-out mice were protected from the decrease in alveolar macrophage 5-lipoxygenase metabolism. iNOS regulates alveolar macrophage 5-lipoxygenase metabolism following endotoxin exposure.
- University of Michigan–Ann Arbor United States
- Eastern Michigan University United States
Lipopolysaccharides, Mice, Knockout, Leukotrienes, Arachidonate 5-Lipoxygenase, Down-Regulation, Nitric Oxide Synthase Type II, Rats, Specific Pathogen-Free Organisms, Mice, Inbred C57BL, Interferon-gamma, Mice, Enzyme Induction, Sepsis, Macrophages, Alveolar, Animals, Female, Nitric Oxide Synthase, Rats, Wistar, Cecum, Ligation
Lipopolysaccharides, Mice, Knockout, Leukotrienes, Arachidonate 5-Lipoxygenase, Down-Regulation, Nitric Oxide Synthase Type II, Rats, Specific Pathogen-Free Organisms, Mice, Inbred C57BL, Interferon-gamma, Mice, Enzyme Induction, Sepsis, Macrophages, Alveolar, Animals, Female, Nitric Oxide Synthase, Rats, Wistar, Cecum, Ligation
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