Subunit Composition of Kainate Receptors in Hippocampal Interneurons
Copyright policy )Subunit Composition of Kainate Receptors in Hippocampal Interneurons
Kainate receptor activation affects GABAergic inhibition in the hippocampus by mechanisms that are thought to involve the GluR5 subunit. We report that disruption of the GluR5 subunit gene does not cause the loss of functional KARs in CA1 interneurons, nor does it prevent kainate-induced inhibition of evoked GABAergic synaptic transmission onto CA1 pyramidal cells. However, KAR function is abolished in mice lacking both GluR5 and GluR6 subunits, indicating that KARs in CA1 stratum radiatum interneurons are heteromeric receptors composed of both subunits. In addition, we show the presence of presynaptic KARs comprising the GluR6 but not the GluR5 subunit that modulate synaptic transmission between inhibitory interneurons. The existence of two separate populations of KARs in hippocampal interneurons adds to the complexity of KAR localization and function.
- University of Basel Switzerland
- Centre national de la recherche scientifique France
- Salk Institute for Biological Studies United States
- University of Bordeaux France
- French National Centre for Scientific Research France
Mice, Knockout, Kainic Acid, Patch-Clamp Techniques, Dose-Response Relationship, Drug, Neuroscience(all), Pyramidal Cells, Down-Regulation, Mice, Inbred Strains, Neural Inhibition, Hippocampus, Mice, Protein Subunits, Receptors, Kainic Acid, Interneurons, Neuromuscular Depolarizing Agents, Animals, Neurons, Afferent, Receptors, AMPA, Excitatory Amino Acid Antagonists, Cells, Cultured, Crosses, Genetic
Mice, Knockout, Kainic Acid, Patch-Clamp Techniques, Dose-Response Relationship, Drug, Neuroscience(all), Pyramidal Cells, Down-Regulation, Mice, Inbred Strains, Neural Inhibition, Hippocampus, Mice, Protein Subunits, Receptors, Kainic Acid, Interneurons, Neuromuscular Depolarizing Agents, Animals, Neurons, Afferent, Receptors, AMPA, Excitatory Amino Acid Antagonists, Cells, Cultured, Crosses, Genetic
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