Human arylamineN‐acetyltransferase 2 polymorphism and susceptibility to allergic contact dermatitis
Copyright policy )Human arylamineN‐acetyltransferase 2 polymorphism and susceptibility to allergic contact dermatitis
AbstractBackground N‐acetyltransferase 2 (NAT2) polymorphism may be involved in the pathogenesis of allergic contact dermatitis.Objective The present study was designed to evaluate whether acetylation polymorphism plays a role in the susceptibility top‐Phenylenediamine (PPD) sensitization.Methods The frequencies of sevenNAT2point mutations, namely G191A, C282T, T341C, C481T, G590A, A803G, and G857A, and genotypes were determined by PCR/RFLP in a total of 70 patients with allergic contact dermatitis to PPD and 100 control subjects with no history of allergy, atopy, lung disease, diabetes mellitus and cancer.Results Genotypes coding rapid acetylation were detected in 52.9% and 37.0% of patients with contact dermatitis and control subjects, respectively (P = 0.04). The frequency of theNAT2*4 allele andNAT2*4/*4 genotype, coding for rapid acetylation, were also significantly higher in the contact dermatitis patients than in the control subjects (P = 0.003).Conclusion Our results suggest an association between rapid acetylation polymorphism and susceptibility to PPD sensitization.
- Gaziantep University Turkey
Adult, Male, Polymorphism, Genetic, Adolescent, Genotype, Arylamine N-Acetyltransferase, Acetylation, Middle Aged, Phenylenediamines, Dermatitis, Allergic Contact, Humans, Point Mutation, Female, Genetic Predisposition to Disease, Coloring Agents, Alleles, Aged
Adult, Male, Polymorphism, Genetic, Adolescent, Genotype, Arylamine N-Acetyltransferase, Acetylation, Middle Aged, Phenylenediamines, Dermatitis, Allergic Contact, Humans, Point Mutation, Female, Genetic Predisposition to Disease, Coloring Agents, Alleles, Aged
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