The Human and Mouse Receptors for Hyaluronan-Mediated Motility, RHAMM, Genes (HMMR) Map to Human Chromosome 5q33.2–qter and Mouse Chromosome 11
Copyright policy )The Human and Mouse Receptors for Hyaluronan-Mediated Motility, RHAMM, Genes (HMMR) Map to Human Chromosome 5q33.2–qter and Mouse Chromosome 11
The gene for the receptor for hyaluronan-mediated motility, RHAMM (designated hyaluronan-mediated motility receptor, HMMR (human) and Hmmr (mouse), for mapping purposes), was localized to human chromosome 5q33.2-qter by somatic cell and radiation hybrid analyses. Investigation of two interspecific backcrosses localized the mouse RHAMM (Hmmr) locus 18 cM from the centromere of mouse chromosome 11 within a region of synteny homology with human chromosome 5q23-q35 genes. The map position of the human RHAMM gene places it in a region comparatively rich in disease-associated genes, including those for low-frequency hearing loss, dominant limb-girdle muscular dystrophy, diastrophic dysplasia, Treacher Collins syndrome, and myeloid disorders associated with the 5q- syndrome. The RHAMM gene location and its ability to transform cells when overexpressed implicate RHAMM as a possible candidate gene in the pathogenesis of the recently described t(5;14)(q33-q34;q11) acute lymphoblastic leukemias.
- University of Michigan–Flint United States
- Mayo Clinic United States
- National Institute of Health Pakistan
- University of Manitoba Canada
- University of California, Irvine United States
Genetic Markers, Base Sequence, Carcinoma, Centromere, Molecular Sequence Data, Chromosome Mapping, Breast Neoplasms, Hybrid Cells, Polymerase Chain Reaction, Mice, Inbred C57BL, Mice, Hyaluronan Receptors, Haplotypes, Tumor Cells, Cultured, Animals, Chromosomes, Human, Pair 5, Humans, Crosses, Genetic
Genetic Markers, Base Sequence, Carcinoma, Centromere, Molecular Sequence Data, Chromosome Mapping, Breast Neoplasms, Hybrid Cells, Polymerase Chain Reaction, Mice, Inbred C57BL, Mice, Hyaluronan Receptors, Haplotypes, Tumor Cells, Cultured, Animals, Chromosomes, Human, Pair 5, Humans, Crosses, Genetic
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