Biophysical Journal
Article . 2009
License: Elsevier Non-Commercial
Data sources: BASE (Open Access Aggregator)
Biophysical Journal
Article . 2009 . Peer-reviewed
License: Elsevier Non-Commercial
Data sources: Crossref
The Role Of Dynamics On Binding Specificity And Promiscuity
Authors: Ozkirimli, Elif; Keskin, Ozlem;
The Role Of Dynamics On Binding Specificity And Promiscuity
Abstract
Protein - protein interactions regulate and control a wide range of physiological processes. Protein interaction networks abound with proteins that have only a few connections while a small number of proteins, which are called hub proteins, are highly connected. Recent reports suggest that hub proteins are structurally and dynamically different from non-hub proteins. Hub proteins tend to be more disordered than other proteins. Further, binding partners of hub proteins are also observed to have higher levels of disorder. Here we perform a detailed examination of hub and non-hub proteins using the Gaussian Network Model (GNM) to elucidate the role of intrinsic dynamics for binding diversity and promiscuity.
Related Organizations
- Koç University Turkey
- Boğaziçi University Turkey
Keywords
Biophysics
Biophysics
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
popularity
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This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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