Cross-Neutralization of Emerging SARS-CoV-2 Variants of Concern by Antibodies Targeting Distinct Epitopes on Spike
Copyright policy )Cross-Neutralization of Emerging SARS-CoV-2 Variants of Concern by Antibodies Targeting Distinct Epitopes on Spike
We describe the binding and neutralization properties of a new set of human monoclonal antibodies derived from memory B cells of 10 coronavirus disease 2019 (COVID-19) convalescent donors in the first pandemic wave of prototype SARS-CoV-2. There were 12 antibodies targeting distinct epitopes on spike, including two sites on the RBD and one on the N-terminal domain (NTD), that displayed cross-neutralization of VOCs, for which distinct antibody targets could neutralize discrete variants.
- University of Tokyo Japan
- Seattle Children's Research Institute United States
- University of Washington United States
- University of Mary United States
- University of Wisconsin System United States
Adult, Male, infectious disease, Antibodies, Viral, immune memory, Microbiology, Article, Epitopes, Plasma, Neutralization Tests, humoral immunity, Humans, Pandemics, SARS-CoV-2, Antibodies, Monoclonal, COVID-19, Convalescence, Middle Aged, QR1-502, single cell, Spike Glycoprotein, Coronavirus, Female, monoclonal antibodies, Broadly Neutralizing Antibodies, Research Article, Protein Binding
Adult, Male, infectious disease, Antibodies, Viral, immune memory, Microbiology, Article, Epitopes, Plasma, Neutralization Tests, humoral immunity, Humans, Pandemics, SARS-CoV-2, Antibodies, Monoclonal, COVID-19, Convalescence, Middle Aged, QR1-502, single cell, Spike Glycoprotein, Coronavirus, Female, monoclonal antibodies, Broadly Neutralizing Antibodies, Research Article, Protein Binding
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