CNR/Pcdhα family in subplate neurons, and developing cortical connectivity
Copyright policy )CNR/Pcdhα family in subplate neurons, and developing cortical connectivity
The cadherin-related neuronal receptor (CNR)/protocadherin (Pcdh) alpha family is one of the diverse protocadherin families identified as a candidate diversified membrane-associated component regulating the formation of neuronal connectivity. However, its expression during neural circuit formation has not been examined in detail. Here, we used a conserved sequence to study the expression of this protein family during the development of neocortical connectivity, by immunohistochemistry and in situ hybridization. The proteins were detected in developing thalamocortical and corticofugal axons, and in subplate neurons, which pioneer these axon tracts. The expression in subplate neurons was confirmed by birth-date labeling with BrdU, and by examination in homozygous reeler mice. This pattern of CNR/Pcdhalpha expression suggests its involvement in the development of neocortical connectivity.
Male, Mice, Inbred ICR, Indoles, Cell Adhesion Molecules, Neuronal, Blotting, Western, Gene Expression Regulation, Developmental, Embryo, Mammalian, Immunohistochemistry, Cell Line, Mice, Inbred C57BL, Mice, Mice, Neurologic Mutants, Bromodeoxyuridine, Chondroitin Sulfate Proteoglycans, Contactin 2, Animals, Humans, Female, Leukocyte L1 Antigen Complex, In Situ Hybridization
Male, Mice, Inbred ICR, Indoles, Cell Adhesion Molecules, Neuronal, Blotting, Western, Gene Expression Regulation, Developmental, Embryo, Mammalian, Immunohistochemistry, Cell Line, Mice, Inbred C57BL, Mice, Mice, Neurologic Mutants, Bromodeoxyuridine, Chondroitin Sulfate Proteoglycans, Contactin 2, Animals, Humans, Female, Leukocyte L1 Antigen Complex, In Situ Hybridization
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