Structure-based design and subsequent optimization of 2-tolyl-(1,2,3-triazol-1-yl-4-carboxamide) inhibitors of p38 MAP kinase
Copyright policy )Structure-based design and subsequent optimization of 2-tolyl-(1,2,3-triazol-1-yl-4-carboxamide) inhibitors of p38 MAP kinase
A computer-aided drug design strategy leads to the identification of a new class of p38 inhibitors based on the 2-tolyl-(1,2,3-triazol-1-yl-4-carboxamide) scaffold. The tolyl triazole amides provided a potent platform amenable to optimization. Further exploration leads to compounds with greater than 100-fold improvement in binding affinity to p38. Derivatives prepared to alter the physicochemical properties produced inhibitors with IC(50)'s in human whole blood as low as 83 nM.
- Boehringer Ingelheim (United States) United States
- Boehringer Ingelheim Fonds Germany
Binding Sites, Molecular Structure, Triazoles, p38 Mitogen-Activated Protein Kinases, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Design, Computer-Aided Design, Humans, Enzyme Inhibitors
Binding Sites, Molecular Structure, Triazoles, p38 Mitogen-Activated Protein Kinases, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Design, Computer-Aided Design, Humans, Enzyme Inhibitors
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