Chromosomal Localization of Muscle Nicotinic Acetylcholine Receptor Genes in the Mouse
Copyright policy )Chromosomal Localization of Muscle Nicotinic Acetylcholine Receptor Genes in the Mouse
The chromosomal localization of the genes encoding the four subunits of muscle nicotinic receptor was determined by analyzing restriction fragment length polymorphisms between two mouse species Mus musculus domesticus (DBA/2) and Mus spretus (SPE). Analysis of the progeny of the interspecies mouse backcross (DBA/2 × SPE) × DBA/2 showed that the α-subunit gene cosegregates with the α-cardiac actin gene on chromosome 17, that the β-subunit gene is located on chromosome 11, and that the γ- and δ-subunit genes cosegregate and are located on chromosome 1.
- Institut Pasteur France
- University of Mary United States
- Washington University in St. Louis United States
Polymorphism, Genetic, Muscles, Chromosome Mapping, Nucleic Acid Hybridization, DNA, DNA Restriction Enzymes, Receptors, Nicotinic, Actins, Muridae, Mice, Species Specificity, Mice, Inbred DBA, Animals, Crosses, Genetic
Polymorphism, Genetic, Muscles, Chromosome Mapping, Nucleic Acid Hybridization, DNA, DNA Restriction Enzymes, Receptors, Nicotinic, Actins, Muridae, Mice, Species Specificity, Mice, Inbred DBA, Animals, Crosses, Genetic
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