Conservation and diversity in families of coated vesicle adaptins.
Copyright policy )Conservation and diversity in families of coated vesicle adaptins.
The complete sequence of the beta adaptin subunit of the plasma membrane adaptor complex from coated vesicles has been elucidated. Complementary cDNA clones from human fibroblasts, rat lymphocytes, and bovine lymphocytes have been isolated, sequenced, and compared with each other and with beta adaptin sequences from rat brain (Kirchhausen, T., Nathanson, K.L., Matsui, W., Vaisberg, A., Chow, E.P., Burne, C., Keen, J.H., and Davis, A.E. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 2612-2616). Surprisingly, the 937-amino acid beta adaptin polypeptide is totally conserved between species. This remarkable homology contrasts with the absence of significant sequence similarity between the alpha (Robinson, M.S. (1989) J. Cell Biol. 108, 833-842) and beta adaptins of the plasma membrane adaptor complex. Diversity within each adaptin family is created by the expression of different genes and by tissue-specific differential splicing. The structures of the beta and alpha adaptins can both be divided into two globular domains interconnected by a variable and potentially flexible stalk domain.
- Stanford University United States
Base Sequence, Protein Conformation, Molecular Sequence Data, Brain, Proteins, Coated Pits, Cell-Membrane, Endosomes, Rats, Models, Structural, Adaptor Proteins, Vesicular Transport, Adaptor Protein Complex alpha Subunits, Sequence Homology, Nucleic Acid, Animals, Humans, Adaptor Protein Complex beta Subunits, Cattle, Amino Acid Sequence, Cloning, Molecular, Oligonucleotide Probes, Gene Library
Base Sequence, Protein Conformation, Molecular Sequence Data, Brain, Proteins, Coated Pits, Cell-Membrane, Endosomes, Rats, Models, Structural, Adaptor Proteins, Vesicular Transport, Adaptor Protein Complex alpha Subunits, Sequence Homology, Nucleic Acid, Animals, Humans, Adaptor Protein Complex beta Subunits, Cattle, Amino Acid Sequence, Cloning, Molecular, Oligonucleotide Probes, Gene Library
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).92 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!