Modulation of the mitochondrial voltage dependent anion channel (VDAC) by curcumin
Copyright policy )Modulation of the mitochondrial voltage dependent anion channel (VDAC) by curcumin
Voltage dependent anion channel (VDAC) of mitochondria plays a crucial role in apoptosis. Human VDAC-1, reconstituted in planar lipid bilayer showed reduced conductance when treated with curcumin. Curcumin interacts with residues in the α helical N-terminus of VDAC and in the channel wall, as revealed by molecular docking, followed by mutational analysis. N-terminus mimicking peptide showed conformational changes in circular dichroism, upon curcumin treatment. We propose that the interaction of curcumin with amino acids in N-terminus and in channel wall fixes the α helix in closed conformation. This restricts its movement which is required for the opening of the channel.
Curcumin, Vdac, Blotting, Western, Lipid Bilayers, Biophysics, Apoptosis, Biochemistry, Protein Structure, Secondary, Bcl-2 Family, Mitochondrial Proteins, Ion Channel, Mechanisms, Animals, Humans, Cell-Death, Permeability Transition, Binding Sites, VDAC, Dose-Response Relationship, Drug, Molecular Structure, Circular Dichroism, Voltage-Dependent Anion Channel 1, Membrane, Proteins, Cell Biology, Mitochondria, Protein Structure, Tertiary, Molecular Docking Simulation, Bax, Spectrophotometry, Mutation, Cattle, Involvement, Ion channel, Gating, Ion Channel Gating, Cytochrome-C Release, Protein Binding
Curcumin, Vdac, Blotting, Western, Lipid Bilayers, Biophysics, Apoptosis, Biochemistry, Protein Structure, Secondary, Bcl-2 Family, Mitochondrial Proteins, Ion Channel, Mechanisms, Animals, Humans, Cell-Death, Permeability Transition, Binding Sites, VDAC, Dose-Response Relationship, Drug, Molecular Structure, Circular Dichroism, Voltage-Dependent Anion Channel 1, Membrane, Proteins, Cell Biology, Mitochondria, Protein Structure, Tertiary, Molecular Docking Simulation, Bax, Spectrophotometry, Mutation, Cattle, Involvement, Ion channel, Gating, Ion Channel Gating, Cytochrome-C Release, Protein Binding
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