descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2014 English Publisher:Elsevier BVJournal:Kidney International, volume 86, pages 232-234 (issn: 0085-2538,

Authors: M. Gallieni; M. Fusaro;

doi: 10.1038/ki.2014.24

pmid: 25079019

handle: 20.500.14243/378439 , 2434/240016

Vitamin K and cardiovascular calcification in CKD: is patient supplementation on the horizon?

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Abstract

The vitamin K-dependent proteins (VKDPs) matrix Gla protein and osteocalcin protect from cardiovascular calcifications and bone fractures. A vitamin K recycling system maintains sufficient vitamin K levels for activation of VKDPs through γ-glutamyl carboxylase (GGCX). Kaesler et al. demonstrate that uremia per se can interfere with GGCX activity, contributing to vitamin K deficiency in chronic kidney disease and opening the path to the clinical use of vitamin K, currently tested in randomized trials.

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Keywords

vitamin K, Male, Vitamin K, nephrology, Animals, cardiovascular calcification, Uremia

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