Behavioral effects of neonatal lesions on the cerebellar system
Copyright policy )Behavioral effects of neonatal lesions on the cerebellar system
AbstractSeveral rodent models with spontaneous mutations causing cerebellar pathology are impaired in motor functions during the neonatal period, including Grid2Lc, Rorasg, Dab1scm, Girk2Wv, Lmx1adr‐sst, Myo5adn, Inpp4awbl, and Cacna1arol mice as well as shaker and dystonic rats. Deficits are also evident in murine null mutants such as Zic1, Fgfr1/FgFr2, and Xpa/Ercc8. Behavioral deficits are time‐dependent following X‐irradiated‐ or aspiration‐induced lesions of the cerebellum in rats. In addition, motor functions are deficient after lesions in cerebellar‐related pathways. As in animal subjects, sensorimotor disturbances have been described in children with cerebellar lesions. These results underline the importance of the cerebellum and its connections in the development of motor functions.
- University of Lorraine France
- University of Lorraine France
- Centre Hospitalier Universitaire de Nancy France
- Normandie Université France
- University of Rouen France
Time Factors, Developmental Disabilities, 610, Aspirations, Psychological, Motor Activity, Wire suspension, Rats, Mutant Strains, Paw-clasping, Mice, Cerebellar Diseases, Cerebellum, Rotorod, X-Irradiation, Animals, Stationary beam, Radiation Injuries, Cerebellar mutants, Neurons, Mental Disorders, Nuclear Receptor Subfamily 1, Group F, Member 1, SHIRPA, Mice, Mutant Strains, Rats, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Animals, Newborn, Purkinje cells, Body righting, Mutation, Motor coordination, [SDV.IMM]Life Sciences [q-bio]/Immunology, Granule cells
Time Factors, Developmental Disabilities, 610, Aspirations, Psychological, Motor Activity, Wire suspension, Rats, Mutant Strains, Paw-clasping, Mice, Cerebellar Diseases, Cerebellum, Rotorod, X-Irradiation, Animals, Stationary beam, Radiation Injuries, Cerebellar mutants, Neurons, Mental Disorders, Nuclear Receptor Subfamily 1, Group F, Member 1, SHIRPA, Mice, Mutant Strains, Rats, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Animals, Newborn, Purkinje cells, Body righting, Mutation, Motor coordination, [SDV.IMM]Life Sciences [q-bio]/Immunology, Granule cells
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).15 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!