Effect of CCR5-Δ32 Heterozygosity on the Risk of Perinatal HIV-1 Infection: A Meta-Analysis
Copyright policy )Effect of CCR5-Δ32 Heterozygosity on the Risk of Perinatal HIV-1 Infection: A Meta-Analysis
Several studies have investigated whether heterozygosity for a 32-basepair deletion in the CC chemokine receptor 5 gene (CCR5-Delta32 ) affects susceptibility to perinatal HIV-1 infection, but results have been inconclusive. We performed a meta-analysis of published data from 11 studies of HIV-1 perinatally exposed children who were genotyped for the CCR5-Delta32 polymorphism. The crude overall HIV-1 infection rates, by simple data pooling, were 20% (one of five) amongCCR5-Delta32 homozygote children, 39% (131 of 335) among CCR5-Delta32 heterozygote children, and 40% (1408 of 3526) among wild-type CCR5 homozygote children. Compared with wild-type homozygotes, the random effects risk ratio for heterozygotes was 1.04 (95% confidence interval [CI], 0.92-1.17) among all children (N = 3861) and 1.03 (95% CI, 0.90-1.17) among those of European descent (n = 2890). Results were similar when adjusted for the available data on the CCR2-641 polymorphism (n = 1542). The meta-analysis clarifies that perinatal infection is not significantly altered by heterozygosity for CCR5-Delta32 in the child.
- National Cancer Institute United States
- Foundation for Research and Technology Hellas Greece
- University of Mary United States
- Division of Cancer Epidemiology and Genetics United States
- Tufts University United States
Male, Heterozygote, *Infectious Disease Transmission, Vertical, Receptors, CCR5, Continental Population Groups/genetics, HIV Infections, Europe/ethnology, Pregnancy, Risk Factors, HIV-1/physiology, Humans, Polymorphism, Genetic/genetics, Receptors, CCR5/*genetics, Polymorphism, Genetic, HIV Infections/ethnology/*genetics/*transmission, Homozygote, Racial Groups, Infant, Newborn, Infectious Disease Transmission, Vertical, Europe, HIV-1, Female, *Heterozygote
Male, Heterozygote, *Infectious Disease Transmission, Vertical, Receptors, CCR5, Continental Population Groups/genetics, HIV Infections, Europe/ethnology, Pregnancy, Risk Factors, HIV-1/physiology, Humans, Polymorphism, Genetic/genetics, Receptors, CCR5/*genetics, Polymorphism, Genetic, HIV Infections/ethnology/*genetics/*transmission, Homozygote, Racial Groups, Infant, Newborn, Infectious Disease Transmission, Vertical, Europe, HIV-1, Female, *Heterozygote
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