Differences in the N Termini of Herpes Simplex Virus Type 1 and 2 gDs That Influence Functional Interactions with the Human Entry Receptor Nectin-2 and an Entry Receptor Expressed in Chinese Hamster Ovary Cells
Copyright policy )Differences in the N Termini of Herpes Simplex Virus Type 1 and 2 gDs That Influence Functional Interactions with the Human Entry Receptor Nectin-2 and an Entry Receptor Expressed in Chinese Hamster Ovary Cells
ABSTRACT Amino acid differences at seven positions in the N termini of the glycoproteins D (gDs) specified by herpes simplex virus type 1 (HSV-1) and HSV-2 are largely responsible for the significantly higher cell fusion activity of HSV-2 gD with Chinese hamster ovary cells expressing human nectin-2 or only an endogenous hamster receptor.
- Northwestern University Philippines
- Northwestern University United States
Models, Molecular, Sequence Homology, Amino Acid, Molecular Sequence Data, Nectins, CHO Cells, Membrane Fusion, Protein Structure, Tertiary, Viral Envelope Proteins, Cricetinae, Animals, Humans, Receptors, Virus, Amino Acid Sequence, Cell Adhesion Molecules, Plasmids
Models, Molecular, Sequence Homology, Amino Acid, Molecular Sequence Data, Nectins, CHO Cells, Membrane Fusion, Protein Structure, Tertiary, Viral Envelope Proteins, Cricetinae, Animals, Humans, Receptors, Virus, Amino Acid Sequence, Cell Adhesion Molecules, Plasmids
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