Mitotic Exit
Copyright policy )Mitotic Exit
Completion of mitosis is triggered by the activation of the Ras-like GTP-binding protein Tem1p. In the November 30, 2001 issue of Cell, Hu et al. suggest that Tem1p activation is achieved by inhibition of its two-component GAP Bub2p/Bfa1p via phosphorylation of Bfa1p by the Polo kinase Cdc5p. Interestingly, activation of spindle checkpoints inhibits Bfa1p phosphorylation, suggesting that these signaling pathways prevent mitotic exit by maintaining the GAP activity of Bub2p/Bfa1p.
- University of Lausanne Switzerland
- SIB Swiss Institute of Bioinformatics Switzerland
Saccharomyces cerevisiae Proteins, Mitosis, Cell Cycle Proteins, Cell Biology, Protein Serine-Threonine Kinases, Fungal Proteins, Cytoskeletal Proteins, Yeasts, Molecular Biology, Protein Kinases, Monomeric GTP-Binding Proteins
Saccharomyces cerevisiae Proteins, Mitosis, Cell Cycle Proteins, Cell Biology, Protein Serine-Threonine Kinases, Fungal Proteins, Cytoskeletal Proteins, Yeasts, Molecular Biology, Protein Kinases, Monomeric GTP-Binding Proteins
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