CDYL Deficiency Disrupts Neuronal Migration and Increases Susceptibility to Epilepsy
Copyright policy )CDYL Deficiency Disrupts Neuronal Migration and Increases Susceptibility to Epilepsy
During brain development, the correct migration of newborn neurons is one of the determinants of circuit formation, and neuronal migration defects may lead to neurological and psychiatric disorders. The molecular mechanisms underlying neuronal migration and related disorders are poorly understood. Here, we report that Chromodomain Y-like (CDYL) is critical for neuronal migration in mice. Knocking down CDYL caused neuronal migration defects and disrupted both mobility and multipolar-to-bipolar transition of migrating neurons. We find that CDYL regulates neuronal migration by transcriptionally repressing RhoA. In addition, CDYL deficiency increased the excitability of cortical pyramidal neurons and the susceptibility of mice to convulsant-induced seizures. These results demonstrate that CDYL is a regulator of neuronal migration and shed light on the pathogenesis of seizure-related neurodevelopmental disorders.
- Peking University China (People's Republic of)
- State Key Laboratory of Neuroscience China (People's Republic of)
- National Health and Family Planning Commission China (People's Republic of)
- McGovern Institute for Brain Research, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA United States
- Peking University China (People's Republic of)
Male, Neurons, Mice, Inbred ICR, Epilepsy, QH301-705.5, Brain, Cell Polarity, Actins, Chromatin, Polymerization, Histones, Mice, Inbred C57BL, Actin Cytoskeleton, Cell Movement, Gene Knockdown Techniques, Animals, Pentylenetetrazole, Disease Susceptibility, Biology (General), Co-Repressor Proteins, Hydro-Lyases, Histone Acetyltransferases
Male, Neurons, Mice, Inbred ICR, Epilepsy, QH301-705.5, Brain, Cell Polarity, Actins, Chromatin, Polymerization, Histones, Mice, Inbred C57BL, Actin Cytoskeleton, Cell Movement, Gene Knockdown Techniques, Animals, Pentylenetetrazole, Disease Susceptibility, Biology (General), Co-Repressor Proteins, Hydro-Lyases, Histone Acetyltransferases
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