Effect of SNP at position 40237 in exon 7 of the TPH2 gene on susceptibility to suicide
Copyright policy )Effect of SNP at position 40237 in exon 7 of the TPH2 gene on susceptibility to suicide
The novel tryptophan hydroxylase isoform (TPH2), being the rate-limiting enzyme in the biosynthesis of serotonin, has many biological functions and plays an important role as candidate gene in several psychiatric disorders. Here, an A-G single nucleotide polymorphism (SNP) at the position 40237 relative to 5'-end of TPH2 gene was selected for the association with suicide behavior.The study population consisted of 102 MD patients with suicide behavior as attempters and 123 MD patients without suicide behavior as non-attempters. The TPH2 SNP was determined by sequencing on an ABI 3700 automated DNA sequencer.The A allele was significantly less frequent in attempters than in non-attempters (p=0.0067). Individuals with the A/A genotype showed a significantly lower risk of suicide behavior than those with the A/G or G/G genotype (OR=0.35).Our findings suggest that the A-G polymorphism of TPH2 may confer susceptibility to suicide behavior in MD patients.
- Shantou University China (People's Republic of)
- Shantou University Medical College China (People's Republic of)
Adult, Male, Depressive Disorder, Major, Suicide, Attempted, Middle Aged, Tryptophan Hydroxylase, Polymorphism, Single Nucleotide, Sex Factors, Gene Frequency, Humans, Female
Adult, Male, Depressive Disorder, Major, Suicide, Attempted, Middle Aged, Tryptophan Hydroxylase, Polymorphism, Single Nucleotide, Sex Factors, Gene Frequency, Humans, Female
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