LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance
Copyright policy )LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance
Key PointsNotch1/DII4-mediated signals are normally suppressed by LRF, preventing HSCs from premature T-cell differentiation in the bone marrow. Erythroblastic islands may have the capacity to regulate the fate and function of HSCs.
- GENENTECH INC United States
- City Of Hope National Medical Center United States
- Harvard University United States
- École Polytechnique Fédérale de Lausanne EPFL Switzerland
- University of Lausanne Switzerland
Mice, Knockout, Erythroblasts, Reverse Transcriptase Polymerase Chain Reaction, Calcium-Binding Proteins, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Bone Marrow Cells, Cell Differentiation, Hematopoietic Stem Cells, Immunohistochemistry, DNA-Binding Proteins, Mice, Inbred C57BL, Mice, Cellular Microenvironment, Animals, Receptor, Notch1, Adaptor Proteins, Signal Transducing, Bone Marrow Transplantation, Cell Proliferation, Oligonucleotide Array Sequence Analysis
Mice, Knockout, Erythroblasts, Reverse Transcriptase Polymerase Chain Reaction, Calcium-Binding Proteins, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Bone Marrow Cells, Cell Differentiation, Hematopoietic Stem Cells, Immunohistochemistry, DNA-Binding Proteins, Mice, Inbred C57BL, Mice, Cellular Microenvironment, Animals, Receptor, Notch1, Adaptor Proteins, Signal Transducing, Bone Marrow Transplantation, Cell Proliferation, Oligonucleotide Array Sequence Analysis
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