Therapeutic effect of co-transplantation of neuregulin 1-transfected-Schwann cells and bone marrow stromal cells on spinal cord hemisection syndrome
Copyright policy )Therapeutic effect of co-transplantation of neuregulin 1-transfected-Schwann cells and bone marrow stromal cells on spinal cord hemisection syndrome
The aim of this present study is to evaluate the therapeutic effect of co-transplantation of neuregulin-1-transfected Schwann cells (SCs) and bone marrow stromal cells (BMSCs) on a rat model of spinal cord hemi-section injuries (Brown-Séquard syndrome), which is relevant to human clinical spinal cord injury. Both in vivo and in vitro data we received demonstrated that co-transplantation BMSCs with NRG1-transfected SCs reduced the size of cystic cavities, promoted axonal regeneration and hind limb functional recovery in comparison with SCs or BMSCs transplantation alone or together, and this treatment could provide important insights into potential therapies of spinal cord hemi-section injuries.
- Harbin Medical University China (People's Republic of)
- Third Affiliated Hospital of Harbin Medical University China (People's Republic of)
Male, Cysts, Neuregulin-1, Bone Marrow Cells, Syndrome, Transfection, Rats, Disease Models, Animal, Animals, Female, Schwann Cells, Rats, Wistar, Stromal Cells, Spinal Cord Injuries, Bone Marrow Transplantation
Male, Cysts, Neuregulin-1, Bone Marrow Cells, Syndrome, Transfection, Rats, Disease Models, Animal, Animals, Female, Schwann Cells, Rats, Wistar, Stromal Cells, Spinal Cord Injuries, Bone Marrow Transplantation
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