Effect of hrWnt7a on Human Retinal Pigment Epithelial Cells In Vitro
Copyright policy )Effect of hrWnt7a on Human Retinal Pigment Epithelial Cells In Vitro
Human recombinant protein Wnt7a (hrWnt7a) inhibits cell proliferative activity and triggers cell polarization. Although cell polarization process was maintained only over a short time, probably via microenvironmental stimuli, hrWnt7a is involved in the transformation of the retinal pigment epithelium. Analysis of Wnt signaling pathway and its regulation will help to understand the processes in retinal pigment epithelial cells under pathological conditions, which can be useful in developing new generation drugs.
- Russian Academy of Sciences Russian Federation
- Helmholtz Moscow Research Institute of Eye Diseases Russian Federation
- Ministry of Health Russian Federation
Cell Polarity, Epithelial Cells, Retinal Pigment Epithelium, Middle Aged, Wnt Proteins, Cell Movement, Humans, Female, Cell Shape, Cells, Cultured, Cell Proliferation
Cell Polarity, Epithelial Cells, Retinal Pigment Epithelium, Middle Aged, Wnt Proteins, Cell Movement, Humans, Female, Cell Shape, Cells, Cultured, Cell Proliferation
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