Assignment of human genes for β2 and β4 subunits of voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23
Copyright policy )Assignment of human genes for β2 and β4 subunits of voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23
We have used human beta 2 and beta 4 cDNA probes to map the genes encoding two isoforms of the regulatory beta subunit of voltage-activated Ca2+ channels, viz. CACNB2 (beta 2) and CACNB4 (beta 4), to human chromosomes 10p12 and 2q22-q23, respectively, by fluorescence in situ hybridization. The gene encoding the beta 2 protein, first described as a Lambert-Eaton myasthenic syndrome (LEMS) antigen in humans, is found close to a region that undergoes chromosome rearrangements in small cell lung cancer, which occurs in association with LEMS. CACNB2 (beta 2) and CACNB4 (beta 4) genes are members of the ion-channel gene superfamily and it should now be possible to examine their loci by linkage analysis of ion-channel-related disorders. To date, no such disease-related gene has been assigned to 10p12 and 2q22-q23.
Lung Neoplasms, Calcium Channels, L-Type, Chromosomes, Human, Pair 10, Molecular Sequence Data, Chromosome Mapping, Lambert-Eaton Myasthenic Syndrome, Electricity, Genes, Chromosomes, Human, Pair 2, Humans, Calcium Channels, Carcinoma, Small Cell, Ion Channel Gating, In Situ Hybridization, Fluorescence
Lung Neoplasms, Calcium Channels, L-Type, Chromosomes, Human, Pair 10, Molecular Sequence Data, Chromosome Mapping, Lambert-Eaton Myasthenic Syndrome, Electricity, Genes, Chromosomes, Human, Pair 2, Humans, Calcium Channels, Carcinoma, Small Cell, Ion Channel Gating, In Situ Hybridization, Fluorescence
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