Changes in the DNA polymerase β gene expression during development of lung, brain, and testis suggest an involvement of the enzyme in DNA recombination

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 1990 English Publisher:Elsevier BVJournal:Experimental Cell Research, volume 191, pages 51-56 (issn: 0014-4827,

Authors: R, Nowak; M, Woszczynski; J A, Siedlecki;

doi: 10.1016/0014-4827(90)90034-8

pmid: 2226650

Changes in the DNA polymerase β gene expression during development of lung, brain, and testis suggest an involvement of the enzyme in DNA recombination

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Abstract

Changes in the expression pattern of DNA polymerase beta gene during rat lung, brain, and testis development have been investigated. A decrease in the level of beta-pol mRNA was observed during postnatal development of lung and brain. By contrast, an almost 20-fold increase in the level of beta-pol mRNA was observed during spermatogenesis. For most adult rat tissues the abundance of beta-pol mRNA was low compared with that of beta-actin mRNA. Northern blot analysis revealed four distinct transcripts hybridizing to beta-pol probes. At least two of them, 1.4 kb and 4.0 kb, were products of a beta-polymerase gene. The changes in the expression pattern during lung and brain development, and during spermatogenesis, suggest involvement of DNA polymerase beta in gap-filling DNA synthesis during recombination.

Keywords

Male, Recombination, Genetic, Brain, Gene Expression, Rats, Inbred Strains, DNA, Blotting, Northern, DNA Polymerase I, Rats, Blotting, Southern, Testis, Animals, RNA, Messenger, Spermatogenesis, Lung

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