Host Determinants of HIV‐1 Control in African Americans
Copyright policy )Host Determinants of HIV‐1 Control in African Americans
We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P = 5.6 x 10(-10)). These analyses therefore confirm a member of the HLA-B*57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701.
- Duke University United States
- National Cancer Institute Malaysia
- Science Applications International Corporation (United States) United States
- Ministry of Health Malaysia
- Walter Reed Army Institute of Research United States
Adult, Male, Adolescent, Genotype, HIV Infections, HLA-C Antigens, Middle Aged, Viral Load, Polymorphism, Single Nucleotide, Black or African American, DNA-Binding Proteins, Young Adult, Phenotype, HLA-B Antigens, Disease Progression, HIV-1, Humans, Genome-Wide Association Study
Adult, Male, Adolescent, Genotype, HIV Infections, HLA-C Antigens, Middle Aged, Viral Load, Polymorphism, Single Nucleotide, Black or African American, DNA-Binding Proteins, Young Adult, Phenotype, HLA-B Antigens, Disease Progression, HIV-1, Humans, Genome-Wide Association Study
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