Lack of association between the apolipoprotein B gene 3‘ hypervariable region alleles and coronary artery disease in Finnish patients with angiographically documented coronary artery disease
Copyright policy )Lack of association between the apolipoprotein B gene 3‘ hypervariable region alleles and coronary artery disease in Finnish patients with angiographically documented coronary artery disease
Abstract. Previous studies have suggested that some apolipoprotein B (apoB) 3′ variable number of tandem repeats (3′VNTR) locus alleles are associated with coronary artery disease (CAD). We examined the possible association between the apoB 3′VNTR alleles and CAD in 387 Finnish subjects. Using the polymerase chain reaction and polyacrylamide gel electrophoresis, the 3′VNTR genotype was determined in 187 individuals with severe CAD confirmed by coronary angiography (patients), in 121 individuals with normal coronary angiograms (controls), and in 79 apparently healthy subjects (normals). In contrast to previous reports from other populations, the larger apoB 3′VNTR alleles were not significantly more frequent among CAD patients than among controls or normals. In addition, there was no significant association between the 3′VNTR alleles and serum lipid levels in this Finnish population.
- King’s University United States
- Columbia University United States
- University of Helsinki Finland
Base Sequence, Molecular Sequence Data, Genetic Variation, Coronary Disease, Middle Aged, Coronary Angiography, Lipids, Polymerase Chain Reaction, Cholesterol, Humans, Alleles, Finland, Apolipoproteins B
Base Sequence, Molecular Sequence Data, Genetic Variation, Coronary Disease, Middle Aged, Coronary Angiography, Lipids, Polymerase Chain Reaction, Cholesterol, Humans, Alleles, Finland, Apolipoproteins B
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