Anteriorization of neural fate by inhibitor of β-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling
Copyright policy )Anteriorization of neural fate by inhibitor of β-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling
Inhibitor of β-catenin and T cell factor (ICAT) inhibits Wnt signaling by interfering with the interaction between β-catenin and T cell factor. Here we show that ICAT –/– embryos exhibit malformation of the forebrain and craniofacial bones and lack the kidney. Analysis of the neuronal differentiation of embryonic stem cells revealed that Wnt3a redirects the fate of neural progenitors to a posterior character, whereas ICAT induces forebrain cells by inhibiting Wnt signaling. Furthermore, ICAT –/– embryonic stem cells were found to differentiate into neuronal cells possessing a posterior character. These results suggest that ICAT plays an important role in the anteriorization of neural cells by inhibiting the posteriorizing activity of Wnt signaling.
- University of Tokyo Japan
- Kyoto University Japan
- Fuji University Japan
- Gunma University Japan
Male, Neurons, Stem Cells, Cell Cycle Proteins, Cell Differentiation, Zebrafish Proteins, Embryo, Mammalian, Mice, Inbred C57BL, Repressor Proteins, Wnt Proteins, Mice, Prosencephalon, Proto-Oncogene Proteins, Animals, Cell Lineage, Female, Cells, Cultured, Adaptor Proteins, Signal Transducing, Signal Transduction, Transcription Factors
Male, Neurons, Stem Cells, Cell Cycle Proteins, Cell Differentiation, Zebrafish Proteins, Embryo, Mammalian, Mice, Inbred C57BL, Repressor Proteins, Wnt Proteins, Mice, Prosencephalon, Proto-Oncogene Proteins, Animals, Cell Lineage, Female, Cells, Cultured, Adaptor Proteins, Signal Transducing, Signal Transduction, Transcription Factors
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