Does ORP150/HSP12A Protect Dopaminergic Neurons Against MPTP/MPP+-Induced Neurotoxicity?
Copyright policy )Does ORP150/HSP12A Protect Dopaminergic Neurons Against MPTP/MPP+-Induced Neurotoxicity?
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and its metabolite 1-methyl-4-phenylpyridinium (MPP(+)) are drugs that are widely used in experimental Parkinson disease (PD) models. What is the significance of ORP150/HSP12A, a molecular chaperone in the endoplasmic reticulum (ER), in the nigrostriatal system? Dopaminergic neuroblastoma SH-SY5Y cells and dopaminergic neurons of the substantia nigra pars compacta (SNpc) were examined. Our observations led to the hypothesis that ORP150 protects against MPTP/MPP(+)-induced neurotoxicity, and indicate the importance of the ER environment in maintaining the nigrostriatal pathways.
- Kanazawa Medical University Japan
- Osaka University Japan
- Hyogo College of Medicine Japan
- Kanazawa University Japan
- National Neuroscience Institute Singapore
Male, Mice, Knockout, Neurons, 1-Methyl-4-phenylpyridinium, Cell Death, Dopamine, Proteins, Adenoviridae, Mice, Inbred C57BL, Mice, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Transduction, Genetic, Cell Line, Tumor, Animals, HSP70 Heat-Shock Proteins
Male, Mice, Knockout, Neurons, 1-Methyl-4-phenylpyridinium, Cell Death, Dopamine, Proteins, Adenoviridae, Mice, Inbred C57BL, Mice, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Transduction, Genetic, Cell Line, Tumor, Animals, HSP70 Heat-Shock Proteins
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