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Chemokine treatment rescues profound T-lineage progenitor homing defect after bone marrow transplant conditioning in mice

descriptionPublicationkeyboard_double_arrow_right Article 10 Jul 2014 English Publisher:American Society of HematologyJournal:Blood, volume 124, pages 296-304 (issn: 0006-4971, eissn: 1528-0020,

Authors: Sugata Manna; Bruce R. Blazar; Daniel A. Zlotoff; Shirley L. Zhang; Avinash Bhandoola; Xinxin Wang; Jerrod L. Bryson;

doi: 10.1182/blood-2014-01-552794

pmid: 24876562

pmc: PMC4093685

Chemokine treatment rescues profound T-lineage progenitor homing defect after bone marrow transplant conditioning in mice

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Abstract

Key PointsHoming of T-lineage progenitors to the thymus is reduced after irradiation. Chemokines limit thymic reconstitution after BMT.

Related Organizations

University of Minnesota Morris
United States
University of Pennsylvania
United States

Keywords

Transplantation Conditioning, Chemokine CCL21, T-Lymphocytes, Mice, Transgenic, Thymus Gland, Lymphoid Progenitor Cells, Mice, Inbred C57BL, Mice, Cell Movement, Chemokines, CC, Animals, Cell Lineage, Female, Cells, Cultured, Bone Marrow Transplantation

13 Research products, page 1 of 2

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	36
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%