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Rheumatology
Article
Data sources: UnpayWall
Rheumatology
Article . 2002 . Peer-reviewed
Data sources: Crossref
Rheumatology
Article . 2002
Data sources: Europe PubMed Central
Rheumatology
Article
Data sources: Microsoft Academic Graph
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Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2002Publisher:Oxford University Press (OUP)Journal:Rheumatology, volume 41, pages 930-936 (eissn: 1460-2172, Copyright policy )
Authors: W. E. R. Ollier; Wendy Thomson; A. Stevans; Athimalaipet V Ramanan; Rachelle Donn; A. Farhan;

doi: 10.1093/rheumatology/41.8.930

pmid: 12154211

Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis

Abstract

To investigate the involvement of neuroendocrine candidate genes in the aetiopathogenesis of juvenile idiopathic arthritis (JIA).Single-nucleotide polymorphisms and intragenic microsatellite markers within five neuroendocrine candidate genes (CRH, CBG, CYP19, ESR1, PRL) were investigated in 463 clinically characterized UK Caucasian JIA patients and a panel of 276 unrelated, healthy UK Caucasian controls.None of the polymorphisms investigated showed any statistically significant associations with JIA.The lack of association with polymorphisms of these neuroendocrine genes suggests that they are not involved in susceptibility to JIA.

Keywords

Genetic Markers, Male, Transcortin, Hypothalamo-Hypophyseal System, Polymorphism, Genetic, Adolescent, Corticotropin-Releasing Hormone, Estrogen Receptor alpha, Pituitary-Adrenal System, Arthritis, Juvenile, Prolactin, Aromatase, Receptors, Estrogen, Reference Values, Humans, Female, Genetic Predisposition to Disease, Child, Alleles, Microsatellite Repeats

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 20
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
Powered by OpenAIRE graph
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
20
Average
Average
Top 10%
bronze