Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3)
Copyright policy )Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3)
The murine JNK-interacting protein 3 (JIP3) protein (also known as JSAP1) is expressed exclusively in neurons and has been identified as a scaffold protein for the c-Jun NH 2 -terminal kinase (JNK) signaling pathway and as an adapter protein for cargo transport by the microtubule motor protein kinesin. To investigate the physiological function of JIP3, we examined the effect of Jip3 gene disruption in mice. The Jip3 – / – mice were unable to breathe and died shortly after birth. Microscopic analysis demonstrated that Jip3 gene disruption causes severe defects in the morphogenesis of the telencephalon. Jip3 – / – mice lack the telencephalic commissure, a major connection between the left and right hemispheres of the brain. The central nervous system abnormalities of Jip3 – / – mice may be accounted for in part by a reduction in signal transduction by RhoA and its effector ROCK.
- Yale University United States
- University of Massachusetts Medical School United States
Telencephalon, Knockout, Vesicular Transport Proteins, Nerve Tissue Proteins, Inbred C57BL, Mice, Munc18 Proteins, Medicine and Health Sciences, Animals, Developmental, *Vesicular Transport Proteins, Adaptor Proteins, Signal Transducing, Mice, Knockout, Signal Transducing, JNK Mitogen-Activated Protein Kinases, Life Sciences, Gene Expression Regulation, Developmental, Proteins, Mice, Inbred C57BL, Gene Expression Regulation, Gene Targeting, *Adaptor Proteins, Mitogen-Activated Protein Kinases, rhoA GTP-Binding Protein, Signal Transduction
Telencephalon, Knockout, Vesicular Transport Proteins, Nerve Tissue Proteins, Inbred C57BL, Mice, Munc18 Proteins, Medicine and Health Sciences, Animals, Developmental, *Vesicular Transport Proteins, Adaptor Proteins, Signal Transducing, Mice, Knockout, Signal Transducing, JNK Mitogen-Activated Protein Kinases, Life Sciences, Gene Expression Regulation, Developmental, Proteins, Mice, Inbred C57BL, Gene Expression Regulation, Gene Targeting, *Adaptor Proteins, Mitogen-Activated Protein Kinases, rhoA GTP-Binding Protein, Signal Transduction
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