Kaposi Sarcoma-Associated Herpesvirus Glycoprotein H Is Indispensable for Infection of Epithelial, Endothelial, and Fibroblast Cell Types
Copyright policy )Kaposi Sarcoma-Associated Herpesvirus Glycoprotein H Is Indispensable for Infection of Epithelial, Endothelial, and Fibroblast Cell Types
All homologues of herpesvirus gH studied to date have been implicated in playing an essential role in viral infection of diverse permissive cell types. However, the role of gH in the mechanism of KSHV infection remains largely unresolved. In this study, we generated a gH-null mutant KSHV and provided evidence that deficiency of gH expression did not affect viral particle assembly or egress. Using the gH-null mutant, we showed that gH was indispensable for KSHV infection of epithelial, endothelial, and fibroblast cellsin vitro. This suggests that gH is an important target for the development of a KSHV prophylactic vaccine to prevent initial viral infection.
- Masinde Muliro University of Science and Technology Kenya
- University of Nairobi Kenya
- Beckman Research Institute United States
- Chapman University United States
- University of Massachusetts Medical School United States
Genetic Processes, glycoprotein H, epithelial, Pharmaceutics and Drug Design, Immunopathology, Genome, Viral, Kaposi sarcoma-associated herpesvirus, fibroblast, Viral Envelope Proteins, vaccine, Virology, endothelial, cancer, Humans, Amino Acids, B cell, tropism, and Proteins, Virion, Endothelial Cells, Epithelial Cells, Genomics, Herpesviridae Infections, Fibroblasts, Virus Internalization, Immunoprophylaxis and Therapy, infection, Medical Cell Biology, Viral Tropism, Immunology of Infectious Disease, Virus Diseases, Medical Microbiology, Viruses, Herpesvirus 8, Human, Mutation, viral entry, Other Pharmacy and Pharmaceutical Sciences, mutation, Genetic Phenomena, Peptides, Medical Genetics
Genetic Processes, glycoprotein H, epithelial, Pharmaceutics and Drug Design, Immunopathology, Genome, Viral, Kaposi sarcoma-associated herpesvirus, fibroblast, Viral Envelope Proteins, vaccine, Virology, endothelial, cancer, Humans, Amino Acids, B cell, tropism, and Proteins, Virion, Endothelial Cells, Epithelial Cells, Genomics, Herpesviridae Infections, Fibroblasts, Virus Internalization, Immunoprophylaxis and Therapy, infection, Medical Cell Biology, Viral Tropism, Immunology of Infectious Disease, Virus Diseases, Medical Microbiology, Viruses, Herpesvirus 8, Human, Mutation, viral entry, Other Pharmacy and Pharmaceutical Sciences, mutation, Genetic Phenomena, Peptides, Medical Genetics
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