GADD45γ regulates the thermogenic capacity of brown adipose tissue
Copyright policy )GADD45γ regulates the thermogenic capacity of brown adipose tissue
Significance Brown adipose tissue (BAT) specializes in converting stored chemical energy into heat. When activated in response to cold, BAT increases the body’s metabolic rate and promotes fat loss. The recent identification of BAT in humans makes activation of this tissue an attractive target for counteracting obesity. However, our understanding of the intracellular pathways that regulate the response to cold is limited. Here, we identify a previously unknown regulator of BAT activation, growth arrest and DNA-damage-inducible protein 45 γ, which is induced in response to cold and works via the MAPK p38 and the transcription factor estrogen-related receptor γ to enhance the expression of genes important for thermogenesis. Our findings may provide new avenues for the stimulation of energy expenditure.
- Stowers Institute for Medical Research United States
- Scripps Research Institute United States
Mice, Knockout, Acclimatization, Intracellular Signaling Peptides and Proteins, Gene Expression, Thermogenesis, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Ion Channels, Cold Temperature, Mice, Inbred C57BL, Mitochondrial Proteins, Mice, Adipose Tissue, Brown, Receptors, Estrogen, Animals, Female, Carrier Proteins, Energy Metabolism, Cells, Cultured, Signal Transduction, Transcription Factors
Mice, Knockout, Acclimatization, Intracellular Signaling Peptides and Proteins, Gene Expression, Thermogenesis, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Ion Channels, Cold Temperature, Mice, Inbred C57BL, Mitochondrial Proteins, Mice, Adipose Tissue, Brown, Receptors, Estrogen, Animals, Female, Carrier Proteins, Energy Metabolism, Cells, Cultured, Signal Transduction, Transcription Factors
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